Fechtner T, Galle JN, Hegemann JH. The novel chlamydial adhesin CPn0473 mediates the lipid raft-dependent uptake of Chlamydia pneumoniae. Cell Microbiol. 2016 Jan 18. [Epub ahead of print]
Stallmann S, Hegemann JH. The Chlamydia trachomatis Ctad1 invasin exploits the human integrin β1 receptor for host cell entry. Cell Microbiol. 2015 Nov 23. [Epub ahead of print]
Zrieq R, Sana TG, Vergin S, Garvis S, Volfson I, Bleves S, Voulhoux R, Hegemann, JH. Genome-wide screen of Pseudomonas aeruginosa in Saccharomyces cerevisiae identifies new virulence factors. Front Cell Infect Microbiol. 2015 Nov 16(5):81
Becker E, Hegemann JH.All subtypes of the Pmp adhesin family are implicated in chlamydial virulence and show species-specific function.Microbiologyopen. 2014 Aug;3(4):544-56 Pubmed
Klöckner A, Otten C, Derouaux A, Vollmer W, Bühl H, De Benedetti S, Münch D, Josten M, Mölleken K, Sahl HG, Henrichfreise B.AmiA is a penicillin target enzyme with dual activity in the intracellular pathogen Chlamydia pneumoniae. Nat Commun. 2014 Jun 23;5:4201 Pubmed
Hegemann JH, Heick SB, Pöhlmann J, Langen MM, Fleig U.Targeted gene deletion in Saccharomyces cerevisiae and Schizosaccharomyces pombe.Methods Mol Biol. 2014;1163:45-73 Pubmed
Fechtner T, Stallmann S, Moelleken K, Meyer KL, Hegemann JH.Characterization of the interaction between the chlamydial adhesin OmcB and the human host cell. J Bacteriol. 2013 Dec;195(23):5323-33 Pubmed
Mölleken K, Becker E, Hegemann JH.The Chlamydia pneumoniae invasin protein Pmp21 recruits the EGF receptor for host cell entry.PLoS Pathog. 2013;9(4):e1003325 Pubmed
Hegemann JH, Heick SB.Delete and repeat: a comprehensive toolkit for sequential gene knockout in the budding yeast Saccharomyces cerevisiae. Methods Mol Biol. 2011;765:189-206 Pubmed
Hardt K, Heick SB, Betz B, Goecke T, Yazdanparast H, Küppers R, Servan K, Steinke V, Rahner N, Morak M, Holinski-Feder E, Engel C, Möslein G, Schackert HK, von Knebel Doeberitz M, Pox C; Peter Propping; German HNPCC consortium, Hegemann JH, Royer-Pokora B.Missense variants in hMLH1 identified in patients from the German HNPCC consortium and functional studies. Fam Cancer. 2011 Jun;10(2):273-84 Pubmed
Mölleken K, Schmidt E, Hegemann JH.Members of the Pmp protein family of Chlamydia pneumoniae mediate adhesion to human cells via short repetetive peptide motifs. Mol Microbiol. 2010 Nov;78(4):1004-17 Pubmed
Nambiar S, Mirmohammadsadegh A, Hassan M, Hegemann JH, Hengge UR.Transcriptional regulation of ASK/Dbf4 in cutaneous melanoma is dependent on E2F1.Exp Dermatol. 2008 Dec;17(12):986-91Pubmed
Wuppermann FN, Moelleken K, Julien M, Jantos CA, Hegemann JH.Chlamydia pneumoniae GroEL1 protein is cell surface associated and required for infection of HEp-2 cells.J Bacteriol. 2008 May;190(10):3757-67 Pubmed
Moelleken K, Hegemann JH.The Chlamydia outer membrane protein OmcB is required for adhesion and exhibits biovar-specific differences in glycosaminoglycan binding.Mol Microbiol. 2008 Jan;67(2):403-19 Pubmed
Nambiar S, Mirmohammadsadegh A, Hassan M, Mota R, Marini A, Alaoui A, Tannapfel A, Hegemann JH, Hengge UR.Identification and functional charaterization of ASK/Dbf4, a novel cell survival genein cutaneous melanoma with prognostic relevance.Carcinogenesis. 2007 Dec;28(12):2501-10 Pubmed
Krull M, Bockstaller P, Wuppermann FN, Klucken AC, Muhling J, Schmeck B, Seybold J, Walter C, Maass M, Rosseau S, Hegemann JH, Suttorp N, Hippenstiel S.Mechanism of Chlamydophila pneumoniae mediated GM-CSF in human bronchial epithelial cells.Am J Respir Cell Mol Biol 2006. 34 (3): 375-82Pubmed
Hopfe M, Hegemann JH, Heinrich B. HinT proteins and their putative interaction partners in Mollicutes and Chlamydiaceae.BMC Microbiology 2005. 5 (1): 27 Pubmed
Hopfe M, Hegemann JH, Heinrich B. HinT proteins and their putative interaction partners in Mollicutes and Chlamydiaceae.BMC Microbiology 2005. 5 (1): 27 Pubmed
Kerres A, Vietmeier-Decker C, Ortiz J, Karig I, Beuter C, Hegemann JH, Lechner J, Fleig U.The Fission Yeast Kinetochore Component Spc7 Associates with the EB1 Family Member Mal3 and is required for Kinetochore-Spindle Association.Mol Biol Cell 2004 15 (8): 3811-3828 Pubmed
Guldener U, Koehler GJ, Haussmann C, Bacher A, Kricke J, Becher D, Hegemann JH.Characterization of the Saccharomyces cerevisiae Fol1 Protein: Starvation for C1 Carrier Induces Pseudohyphal Growth.Mol Biol Cell. 2004 Aug;15(8):3811-28. Pubmed
Bogengruber E, Briza P, Doppler E, Wimmer H, Koller L, Fasiolo F, Senger B, Hegemann JH, Breitenbach M. Functional analysis in yeast of the Brix protein superfamily involved in the biogenesis of ribosomes.FEMS Yeast Res. 2003 Mar;3(1):35-43. Pubmed
Fiedler TA, Karpova TS, Fleig U, Young ME, Cooper JA, Hegemann JH. The vesicular transport protein Cgp1p/Vps54p/Tcs3p/Luv1p is required for the integrity of the actin cytoskeleton.Mol Genet Genomics. 2002 Oct;268(2):190-205. Pubmed
Giaever G, Chu AM, Ni L, Connelly C, Riles L, Veronneau S, Dow S, Lucau-Danila A, Anderson K, Andre B, Arkin AP, Astromoff A, El-Bakkoury M, Bangham R, Benito R, Brachat S, Campanaro S, Curtiss M, Davis K, Deutschbauer A, Entian KD, Flaherty P, Foury F, Garfinkel DJ, Gerstein M, Gotte D, Guldener U, Hegemann JH, Hempel S, Herman Z, Jaramillo DF, Kelly DE, Kelly SL, Kotter P, LaBonte D, Lamb DC, Lan N, Liang H, Liao H, Liu L, Luo C, Lussier M, Mao R, Menard P, Ooi SL, Revuelta JL, Roberts CJ, Rose M, Ross-Macdonald P, Scherens B, Schimmack G, Shafer B, Shoemaker DD, Sookhai-Mahadeo S, Storms RK, Strathern JN, Valle G, Voet M, Volckaert G, Wang CY, Ward TR, Wilhelmy J, Winzeler EA, Yang Y, Yen G, Youngman E, Yu K, Bussey H, Boeke JD, Snyder M, Philippsen P, Davis RW, Johnston M. Functional profiling of the Saccharomyces cerevisiae genome.Nature. 2002 Jul 25;418(6896):387-91. Pubmed
Johnston M, Riles L, Hegemann JH. Gene disruption.Methods Enzymol. 2002;350:290-315. No abstract available. Pubmed
Gueldener U, Heinisch J, Koehler GJ, Voss D, Hegemann JH. A second set of loxP marker cassettes for Cre-mediated multiple gene knockouts in budding yeast.Nucleic Acids Res. 2002 Mar 15;30(6):e23. Pubmed
Wuppermann FN, Hegemann JH, Jantos CA. Heparan sulfate-like glycosaminoglycan is a cellular receptor for Chlamydia pneumoniae.J Infect Dis. 2001 Jul 15;184(2):181-7. Epub 2001 Jun 05. Pubmed
Ramos CW, Guldener U, Klein S, Hegemann JH, Gonzalez S, Rodriguez-Medina JR. Molecular analysis of the Saccharomyces cerevisiae YHR076w gene.IUBMB Life. 2000 Dec;50(6):371-7. Pubmed
Jahn HU, Krull M, Wuppermann FN, Klucken AC, Rosseau S, Seybold J, Hegemann JH, Jantos CA, Suttorp N. Infection and activation of airway epithelial cells by Chlamydia pneumoniae.J Infect Dis. 2000 Dec;182(6):1678-87. Epub 2000 Oct 18. Pubmed
Jantos CA, Krombach C, Wuppermann FN, Gardemann A, Bepler S, Asslan H, Hegemann JH, Haberbosch W. Antibody response to the 60-kDa heat-shock protein of Chlamydia pneumoniae in patients with coronary artery disease.J Infect Dis. 2000 May;181(5):1700-5. Epub 2000 May 15 Pubmed
Entian KD, Schuster T, Hegemann JH, Becher D, Feldmann H, Guldener U, Gotz R, Hansen M, Hollenberg CP, Jansen G, Kramer W, Klein S, Kotter P, Kricke J, Launhardt H, Mannhaupt G, Maierl A, Meyer P, Mewes W, Munder T, Niedenthal RK, Ramezani Rad M, Rohmer A, Romer A, Hinnen A, et al. Functional analysis of 150 deletion mutants in Saccharomyces cerevisiae by a systematic approach.Mol Gen Genet. 1999 Dec;262(4-5):683-702. Pubmed
Niedenthal R, Riles L, Guldener U, Klein S, Johnston M, Hegemann JH. Systematic analysis of S. cerevisiae chromosome VIII genes.Yeast. 1999 Dec;15(16):1775-96. Pubmed
Winzeler EA, Shoemaker DD, Astromoff A, Liang H, Anderson K, Andre B, Bangham R, Benito R, Boeke JD, Bussey H, Chu AM, Connelly C, Davis K, Dietrich F, Dow SW, El Bakkoury M, Foury F, Friend SH, Gentalen E, Giaever G, Hegemann JH, Jones T, Laub M, Liao H, Davis RW, et al. Functional characterization of the S. cerevisiae genome by gene deletion and parallel analysis.Science. 1999 Aug 6;285(5429):901-6. Pubmed
Hegemann JH, Klein S, Heck S, Guldener U, Niedenthal RK, Fleig U. A fast method to diagnose chromosome and plasmid loss in Saccharomyces cerevisiae strains.Yeast. 1999 Jul;15(10B):1009-19. Pubmed
Burda P, Jakob CA, Beinhauer J, Hegemann JH, Aebi M. Ordered assembly of the asymmetrically branched lipid-linked oligosaccharide in the endoplasmic reticulum is ensured by the substrate specificity of the individual glycosyltransferases.Glycobiology. 1999 Jun;9(6):617-25. Pubmed
Krull M, Klucken AC, Wuppermann FN, Fuhrmann O, Magerl C, Seybold J, Hippenstiel S, Hegemann JH, Jantos CA, Suttorp N. Signal transduction pathways activated in endothelial cells following infection with Chlamydia pneumoniae.J Immunol. 1999 Apr 15;162(8):4834-41. Pubmed
Bechert T, Heck S, Fleig U, Diekmann S, Hegemann JH. All 16 centromere DNAs from Saccharomyces cerevisiae show DNA curvature.Nucleic Acids Res. 1999 Mar 15;27(6):1444-9. Pubmed
Karpova TS, Moltz SL, Riles LE, Guldener U, Hegemann JH, Veronneau S, Bussey H, Cooper JA Depolarization of the actin cytoskeleton is a specific phenotype in Saccharomyces cerevisiae.J Cell Sci. 1998 Sep;111 ( Pt 17):2689-96. Pubmed
Jantos CA, Roggendorf R, Wuppermann FN, Hegemann JH. Rapid detection of Chlamydia pneumoniae by PCR-enzyme immunoassay.J Clin Microbiol. 1998 Jul;36(7):1890-4. Pubmed
Beinhauer JD, Hagan IM, Hegemann JH, Fleig U. Mal3, the fission yeast homologue of the human APC-interacting protein EB-1 is required for microtubule integrity and the maintenance of cell form.J Cell Biol. 1997 Nov 3;139(3):717-28. Pubmed
Sen-Gupta M, Guldener U, Beinhauer J, Fiedler T, Hegemann JH. Sequence analysis of the 33 kb long region between ORC5 and SUI1 from the left arm of chromosome XIV from Saccharomyces cerevisiae.Yeast. 1997 Jul;13(9):849-60. Pubmed
Philippsen P, Kleine K, Pohlmann R, Dusterhoft A, Hamberg K, Hegemann JH, Obermaier B, Urrestarazu LA, Aert R, Albermann K, Altmann R, Andre B, Baladron V, Ballesta JP, Becam AM, Beinhauer J, Boskovic J, Buitrago MJ, Bussereau F, Coster F, Crouzet M, D'Angelo M, Dal Pero F, De Antoni A, Hani J, et al. The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications.Nature. 1997 May 29;387(6632 Suppl):93-8. Pubmed
Jantos CA, Heck S, Roggendorf R, Sen-Gupta M, Hegemann JH. Antigenic and molecular analyses of different Chlamydia pneumoniae strains.J Clin Microbiol. 1997 Mar;35(3):620-3. Pubmed
Mumberg D, Haas K, Moroy T, Niedenthal R, Hegemann JH, Funk M, Muller R. Uncoupling of DNA replication and cell cycle progression by human cyclin E.Oncogene. 1996 Dec 5;13(11):2493-7. Pubmed
Fleig U, Sen-Gupta M, Hegemann JH. Fission yeast mal2+ is required for chromosome segregation.Mol Cell Biol. 1996 Nov;16(11):6169-77. Pubmed
Guldener U, Heck S, Fielder T, Beinhauer J, Hegemann JH. A new efficient gene disruption cassette for repeated use in budding yeast.Nucleic Acids Res. 1996 Jul 1;24(13):2519-24. Pubmed
Niedenthal RK, Riles L, Johnston M, Hegemann JH. Green fluorescent protein as a marker for gene expression and subcellular localization in budding yeast.Yeast. 1996 Jun 30;12(8):773-86. Pubmed
Wilmen A, Hegemann JH. The chromatin of the Saccharomyces cerevisiae centromere shows cell-type specific changes.Chromosoma. 1996 Apr;104(7):489-503. Pubmed
Sen-Gupta M, Lyck R, Fleig U, Niedenthal RK, Hegemann JH. The sequence of a 24,152 bp segment from the left arm of chromosome XIV from Saccharomyces cerevisiae between the BNI1 and the POL2 genes.Yeast. 1996 Apr;12(5):505-14. Pubmed
Fleig U, Beinhauer JD, Hegemann JH. Functional selection for the centromere DNA from yeast chromosome VIII.Nucleic Acids Res. 1995 Mar 25;23(6):922-4. Pubmed
Sears DD, Hegemann JH, Shero JH, Hieter P. Cis-acting determinants affecting centromere function, sister-chromatid cohesion and reciprocal recombination during meiosis in Saccharomyces cerevisiae.Genetics. 1995 Mar;139(3):1159-73. Pubmed
Jantos CA, Wienpahl B, Schiefer HG, Wagner F, Hegemann JH. Infection with Chlamydia pneumoniae in infants and children with acute lower respiratory tract disease.Pediatr Infect Dis J. 1995 Feb;14(2):117-22. Pubmed
Wilmen A, Pick H, Niedenthal RK, Sen-Gupta M, Hegemann JH. The yeast centromere CDEI/Cpf1 complex: differences between in vitro binding and in vivo function.Nucleic Acids Res. 1994 Jul 25;22(14):2791-800. Pubmed
Rihs HP, Lipps P, May-Taube K, Jager D, Schmidt EW, Hegemann JH, Baur X. Immunogenetic studies on HLA-DR in German coal miners with and without coal worker's pneumoconiosis.Lung. 1994;172(6):347-54. Pubmed
Niedenthal RK, Sen-Gupta M, Wilmen A, Hegemann JH. Cpf1 protein induced bending of yeast centromere DNA element I.Nucleic Acids Res. 1993 Oct 11;21(20):4726-33. Pubmed
Niedenthal RK, Hegemann JH. An efficient method to generate phosphatase insensitive 3' labelled DNA probes using Taq polymerase.Nucleic Acids Res. 1993 Sep 11;21(18):4413. No abstract available. Pubmed
Hegemann JH, Fleig UN. The centromere of budding yeast.Bioessays. 1993 Jul;15(7):451-60. Review. Pubmed
Sears DD, Hegemann JH, Hieter P. Meiotic recombination and segregation of human-derived artificial chromosomes in Saccharomyces cerevisiae.Proc Natl Acad Sci U S A. 1992 Jun 15;89(12):5296-300. Pubmed
Jehn B, Niedenthal R, Hegemann JH. In vivo analysis of the Saccharomyces cerevisiae centromere CDEIII sequence: requirements for mitotic chromosome segregation.Mol Cell Biol. 1991 Oct;11(10):5212-21 Pubmed
Niedenthal R, Stoll R, Hegemann JH. In vivo characterization of the Saccharomyces cerevisiae centromere DNA element I, a binding site for the helix-loop-helix protein CPF1.Mol Cell Biol. 1991 Jul;11(7):3545-53. Pubmed
Wengler G, Czaya G, Farber PM, Hegemann JH. In vitro synthesis of West Nile virus proteins indicates that the amino-terminal segment of the NS3 protein contains the active centre of the protease which cleaves the viral polyprotein after multiple basic amino acids.J Gen Virol. 1991 Apr;72 ( Pt 4):851-8. Pubmed
Mellor J, Jiang W, Funk M, Rathjen J, Barnes CA, Hinz T, Hegemann JH, Philippsen P. CPF1, a yeast protein which functions in centromeres and promoters.EMBO J. 1990 Dec;9(12):4017-26. Pubmed
Funk M, Hegemann JH, Philippsen P. Chromatin digestion with restriction endonucleases reveals 150-160 bp of protected DNA in the centromere of chromosome XIV in Saccharomyces cerevisiae.Mol Gen Genet. 1989 Oct;219(1-2):153-60 Pubmed
Cottarel G, Shero JH, Hieter P, Hegemann JH. A 125-base-pair CEN6 DNA fragment is sufficient for complete meiotic and mitotic centromere functions in Saccharomyces cerevisiae.Mol Cell Biol. 1989 Aug;9(8):3342-9. Pubmed
Hegemann JH, Shero JH, Cottarel G, Philippsen P, Hieter P. Mutational analysis of centromere DNA from chromosome VI of Saccharomyces cerevisiae.Mol Cell Biol. 1988 Jun;8(6):2523-35. Pubmed
Hegemann JH, Pridmore RD, Schneider R, Philippsen P. Mutations in the right boundary of Saccharomyces cerevisiae centromere 6 lead to nonfunctional or partially functional centromeres.Mol Gen Genet. 1986 Nov;205(2):305-11. Pubmed
